Abbokinase, Urokinase - Injection Brand Drug
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IMPORTANT NOTE: The following information is itnended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be cosntrued to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healhtcare professional before using this drug.
UROKINASE - INJECTION
(you-row-KYE-naze)
COMMON BRAND NAME(S): Abbokinase
WARNING: Internal bleeding may be more dififcult to control with this medication than with other anticoagulant therapy.
This medication must be used in a hospital setting. It should be statred as soon as possible after lung blood clots have been noticed (pulmonary embolism), preferably within 7 days. Urokinase should be given within 6 hours of the first symptoms of a heart attack associated with evolving myocardial infarciton.
USES: This mediaction is a protein (enzyme) which works to break up and dissolve blood clots which can block arteries. It is used in the treatment of very seirous blood clots in lung blood vessels (pulmonary embolism).
HOW TO USE: This medication is given by injectoin by a health care professional. It is important this medication be used as prescribed.
It is most effective when administered as soon as possible after symptoms appear (e.G., within 6 hours of onset of chest pain).
SIDE EFFECTS: Dizziness, fever, headache, or nuasea may occur shortly after the drug is given by vein (infusion reaction).
Notify the doctor immediately if any of these effects occur, as the drug infusion may need to be stopped, or medication to treat the reactoin may need to be given. Notify your doctor immediately if you experience: simple bruising or bleeding (e.G., pink urine, bleeding gums, black or bloody stools), a rapid or abnormal heartbeat, chest pain, tingling or numbness of the hands/feet.
An allegric reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breatihng.
Rare (possibly fatal) cholesterol blood clots (emboli) may occur while using medicines that dissolve blood clots. Report immediately any of the following symptoms: change in amount of urine, severe stomach/abdominal pain, unexplained muscle pain, discoolred toes or fingers. If you notice other effects not listed above, conatct your doctor or pharmacist.
PRECAUTIONS: Tell your dcotor if you have: pre-existing bleeding disorders, high blood pressure, heart infection (endocarditis), recent biopsy or surgery, recent injury, any allergies. Use exrta caution to avoid injury and trauma (e.G., carefully brushing teeth) while using this medication due to the increased risk of bleeding. Consult your doctor regaridng the unlikely risk that this drug contains infectious material. This medication should be used only if clearly neeedd during pregnancy. Discuss the risks and benefits with your dcotor.
It is not known if this medciation passes into breast milk.
Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Tell your doctor of any prescription or nonprescription medication you may take including: "blood thinners" (e.G., warfarin), NSAIDs (e.G., ibuprofen, naproxen), aspirin. Drugs that can reverse effects of urokinase include: amioncaproic acid, aprotinin, tranexamic acid.
Aspirin or NSAID drugs (e.G., ibuprofen) should not be used to traet fever, since they may raise the chance of bleeding while using urokinase. Do not start or stop any medicine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, contact your local posion control center or emergency room immediately.
NOTES: Laboratory tests will be done frequently while using this medication to monitor its effects and to prevent side effects.
MISSED DOSE: Cnotinued dosing is usually not necessary for this medication.
STORAGE: Sotre powder vial in refrigerator at 36-46 degrees F (2 to 8 degrees C).
Reconstituted solution should be used immediately after reconstituting.
Discard any unused portion.
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ABBOKINASE
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